Research workbench
Yeast CTP synthase (URA7) H360R filament bound to substrates
Analyse Yeast CTP synthase (URA7) H360R filament bound to substrates in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RMV
- Type
- protein
- Length
- 4,424 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CTP synthase
- EC
- 6.3.4.2
- UniProt
- A0A7I9CFN1
- Ligands
- ATP, UTP
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 1 distinct chain · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | CTP synthase (EC 6.3.4.2) | protein | 553 | 41% helix, 20% strand | A0A7I9CFN1 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 8 copies · chains A, B, C, D, E, F, G, H
- UTP · Uridine 5'-triphosphate · ligand · 8 copies · chains A, B, C, D, E, F, G, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 815 | 0.87 | 0.89 | 122 | UTP |
| 2 | 786 | 0.86 | 0.89 | 119 | UTP |
| 3 | 237 | 0.66 | 0.84 | 29 | empty |
| 4 | 243 | 0.65 | 0.83 | 32 | empty |
| 5 | 99 | 0.64 | 0.90 | 20 | UTP |
Interfaces
14 interfaces between chains.
- E–H · 1556 Ų buried · 39 hydrogen bonds · protein-protein
- A–D · 1556 Ų buried · 39 hydrogen bonds · protein-protein
- F–G · 1540 Ų buried · 37 hydrogen bonds · protein-protein
- B–C · 1539 Ų buried · 37 hydrogen bonds · protein-protein
- C–F · 1067 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 covalent (covalent ligand).
Compared structures
- 7RMV · Yeast CTP Synthase (Ura7) H360R Filament bound to Substrates · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A7I9CFN1
- Elsewhere: RCSB PDB 7RMV · PDBe 7RMV · UniProt A0A7I9CFN1
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