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Mouse gamma S crystallin L16 octamer

Analyse Mouse gamma S crystallin L16 octamer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7RJ0
Type: protein
Length: 707 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gamma-crystallin S
UniProt: O35486
Pockets: 10 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, C	Gamma-crystallin S	protein	177	9% helix, 38% strand	O35486
D	Gamma-crystallin S	protein	176	2% helix, 37% strand	O35486

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	925	0.78	0.81	79	empty
2	179	0.74	0.91	34	empty
3	551	0.71	0.80	65	empty
4	301	0.63	0.80	37	empty
5	58	0.52	0.87	18	empty

Interfaces

5 interfaces between chains.

B–A · 1237 Å² buried · 8 hydrogen bonds · protein-protein
C–D · 1158 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 529 Å² buried · 3 hydrogen bonds · protein-protein
B–D · 360 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 327 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 modified, 2 disulfide (engineered, disulfide).

Compared structures

7RJ0 · Mouse Gamma S Crystallin L16 Octamer · the same entry in another collection · chain D against D, TM-score 1.00
O35486 · AlphaFold monomer V2.0 prediction for gamma-crystallin S (O35486) · a predicted model of the same protein · chain B against A, TM-score 0.50

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O35486
Elsewhere: RCSB PDB 7RJ0 · PDBe 7RJ0 · UniProt O35486

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