Research workbench
Heterodimer of cre recombinase mutants D33A/A36V/R192A and R72E/L115D/R119D in complex with loxp DNA.
Analyse Heterodimer of cre recombinase mutants D33A/A36V/R192A and R72E/L115D/R119D in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RHZ
- Type
- protein + DNA
- Length
- 703 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Recombinase cre; DNA (44-mer)
- UniProt
- P06956
- Pockets
- 14 · best druggability 0.85
Structure
electron microscopy · 4 distinct chains · 58% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Recombinase cre | protein | 315 | 57% helix, 5% strand | P06956 |
| B | Recombinase cre | protein | 300 | 59% helix, 6% strand | P06956 |
| C | DNA (44-mer) | dna | 44 | — | — |
| D | DNA (44-mer) | dna | 44 | — | — |
Pockets
14 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 973 | 0.85 | 0.87 | 122 | empty |
| 2 | 688 | 0.77 | 0.82 | 65 | empty |
| 3 | 291 | 0.71 | 0.85 | 39 | empty |
| 4 | 122 | 0.70 | 0.91 | 24 | empty |
| 5 | 195 | 0.70 | 0.87 | 43 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2021 Ų buried · 199 hydrogen bonds · nucleic-nucleic
- B–C · 1105 Ų buried · 22 hydrogen bonds · protein-nucleic
- B–D · 1102 Ų buried · 23 hydrogen bonds · protein-nucleic
- A–D · 1061 Ų buried · 24 hydrogen bonds · protein-nucleic
- A–C · 1030 Ų buried · 9 hydrogen bonds · protein-nucleic
Compared structures
- 7RHZ · Heterodimer of Cre recombinase mutants D33A/A36V/R192A and R72E/L115D/R119D in complex… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06956
- Elsewhere: RCSB PDB 7RHZ · PDBe 7RHZ · UniProt P06956
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