Research workbench
Cre recombinase mutant (D33A/A36V/R192A) in complex with loxa DNA hairpin
Analyse Cre recombinase mutant (D33A/A36V/R192A) in complex with loxa DNA hairpin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RHY
- Type
- protein + DNA
- Length
- 350 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Recombinase cre; DNA (49-mer)
- UniProt
- P06956
- Pockets
- 5 · best druggability 0.74
Structure
electron microscopy · 2 distinct chains · 57% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Recombinase cre | protein | 301 | 57% helix, 6% strand | P06956 |
| B | DNA (49-mer) | dna | 49 | — | — |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 957 | 0.74 | 0.78 | 73 | empty |
| 2 | 321 | 0.59 | 0.77 | 25 | empty |
| 3 | 289 | 0.54 | 0.76 | 31 | empty |
| 4 | 91 | 0.35 | 0.74 | 23 | empty |
| 5 | 63 | 0.29 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 2286 Ų buried · 33 hydrogen bonds · protein-nucleic
Compared structures
- 7RHY · Cre recombinase mutant (D33A/A36V/R192A) in complex with loxA DNA hairpin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06956
- Elsewhere: RCSB PDB 7RHY · PDBe 7RHY · UniProt P06956
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