Research workbench
IRF4 transcription factor mutant -K59R
Analyse IRF4 transcription factor mutant -K59R in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RH2
- Type
- protein + DNA
- Length
- 510 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Icsat transcription factor; DNA (5'- D(*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP…
- UniProt
- Q99419
- Pockets
- 13 · best druggability 0.56
Structure
x-ray diffraction · 5 distinct chains · 34% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Icsat transcription factor | protein | 108 | 32% helix, 16% strand | Q99419 |
| B, G, H | Icsat transcription factor | protein | 109 | 36% helix, 16% strand | Q99419 |
| C, D | DNA (5'- D(*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP*GP*C)-3') | dna | 19 | — | — |
| E | DNA (5'- D(*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3') | dna | 19 | — | — |
| F | DNA (5'- D(*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3') | dna | 18 | — | — |
Pockets
13 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 191 | 0.56 | 0.80 | 25 | empty |
| 2 | 52 | 0.50 | 0.87 | 16 | empty |
| 3 | 248 | 0.49 | 0.75 | 29 | empty |
| 4 | 243 | 0.48 | 0.74 | 30 | empty |
| 5 | 147 | 0.48 | 0.78 | 21 | empty |
Interfaces
16 interfaces between chains.
- D–E · 897 Ų buried · 81 hydrogen bonds · nucleic-nucleic
- C–F · 804 Ų buried · 75 hydrogen bonds · nucleic-nucleic
- A–E · 664 Ų buried · 14 hydrogen bonds · protein-nucleic
- F–H · 633 Ų buried · 14 hydrogen bonds · protein-nucleic
- C–H · 537 Ų buried · 11 hydrogen bonds · protein-nucleic
Compared structures
- 7RH2 · IRF4 Transcription factor mutant -K59R · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99419
- Elsewhere: RCSB PDB 7RH2 · PDBe 7RH2 · UniProt Q99419
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