Research workbench
Human retinal variant IMPDH1(595) treated with ATP; interface-centered
Analyse Human retinal variant IMPDH1(595) treated with ATP; interface-centered in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RFF
- Type
- protein
- Length
- 2,712 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 5 of inosine-5'-monophosphate dehydrogenase 1
- EC
- 1.1.1.205
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 41% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Isoform 5 of inosine-5'-monophosphate dehydrogenase 1 (EC 1.1.1.205) | protein | 339 | 41% helix, 16% strand | — |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 463 | 0.84 | 0.91 | 83 | empty |
| 2 | 435 | 0.83 | 0.91 | 75 | empty |
| 3 | 1009 | 0.79 | 0.81 | 109 | empty |
| 4 | 239 | 0.78 | 0.91 | 46 | empty |
| 5 | 255 | 0.77 | 0.90 | 45 | empty |
Interfaces
16 interfaces between chains.
- F–G · 1718 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1705 Ų buried · 25 hydrogen bonds · protein-protein
- E–H · 1692 Ų buried · 23 hydrogen bonds · protein-protein
- G–H · 1686 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 1680 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 7RFF · Human retinal variant IMPDH1(595) treated with ATP; interface-centered · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7RFF · PDBe 7RFF
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