Research workbench
Crystal structure of il-13 in complex with MMAB3 Fab
Analyse Crystal structure of il-13 in complex with MMAB3 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7REW
- Type
- protein
- Length
- 999 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-cyno interleukin 13 Fab heavy chain; Anti-cyno interleukin 13 Fab light chain; IL13
- UniProt
- Q0PW92
- Pockets
- 11 · best druggability 0.65
Structure
x-ray diffraction · 6 distinct chains · 15% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Anti-cyno interleukin 13 Fab heavy chain | protein | 197 | 5% helix, 50% strand | — |
| L | Anti-cyno interleukin 13 Fab light chain | protein | 206 | 7% helix, 48% strand | — |
| A | Anti-cyno interleukin 13 Fab heavy chain | protein | 203 | 6% helix, 51% strand | — |
| B | Anti-cyno interleukin 13 Fab light chain | protein | 208 | 8% helix, 51% strand | — |
| G | IL13 | protein | 92 | 53% helix, 7% strand | Q0PW92 |
| I | IL13 | protein | 93 | 51% helix, 6% strand | Q0PW92 |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 714 | 0.65 | 0.74 | 85 | empty |
| 2 | 507 | 0.61 | 0.74 | 44 | empty |
| 3 | 337 | 0.51 | 0.73 | 54 | empty |
| 4 | 120 | 0.38 | 0.74 | 23 | empty |
| 5 | 95 | 0.36 | 0.75 | 14 | empty |
Interfaces
10 interfaces between chains.
- A–B · 1673 Ų buried · 12 hydrogen bonds · protein-protein
- H–L · 1629 Ų buried · 10 hydrogen bonds · protein-protein
- A–G · 620 Ų buried · 10 hydrogen bonds · protein-protein
- H–I · 604 Ų buried · 11 hydrogen bonds · protein-protein
- B–G · 391 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 7REW · Crystal Structure of IL-13 in complex with MMAb3 Fab · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0PW92
- Elsewhere: RCSB PDB 7REW · PDBe 7REW · UniProt Q0PW92
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.