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Structure of human NTHL1

Analyse Structure of human NTHL1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7RDS
Type: protein
Length: 232 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform 3 of endonuclease III-like protein 1
EC: 3.2.2.-, 4.2.99.18
UniProt: P78549
Ligands: SF4
Pockets: 2 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 56% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isoform 3 of endonuclease III-like protein 1 (EC 3.2.2.-, 4.2.99.18)	protein	232	56% helix, 0% strand	P78549

Ligands and binding sites

SF4 · Iron/sulfur cluster · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	384	0.58	0.75	30	empty
2	63	0.36	0.78	15	empty

Compared structures

7RDS · Structure of human NTHL1 · the same entry in another collection · chain A against A, TM-score 1.00
P78549 · AlphaFold monomer V2.0 prediction for endonuclease III-like protein 1 (P78549) · a predicted model of the same protein · chain A against A, TM-score 0.53

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P78549
Elsewhere: RCSB PDB 7RDS · PDBe 7RDS · UniProt P78549

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