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Crystal structure of pseudooceanicola lipolyticus argonaute bound to 5' oh guide DNA

Analyse Crystal structure of pseudooceanicola lipolyticus argonaute bound to 5' oh… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7R8G
Type: protein + DNA
Length: 784 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Argonaute; DNA (5'- D(*TP*AP*CP*TP*GP*CP*AP*CP*AP*GP*GP*TP*GP*AP*CP*GP*A)-3')
UniProt: A0A2M8J4C7
Pockets: 7 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Argonaute	protein	769	28% helix, 27% strand	A0A2M8J4C7
T	DNA (5'- D(TPAPCPTPGPCPAPCPAPGPGPTPGPAPCPGP*A)-3')	dna	15	—	—

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	365	0.76	0.87	45	empty
2	513	0.76	0.84	53	empty
3	385	0.72	0.83	43	empty
4	124	0.64	0.87	22	empty
5	158	0.50	0.78	21	empty

Interfaces

1 interface between chains.

A–T · 2239 Å² buried · 34 hydrogen bonds · protein-nucleic

Compared structures

7R8G · Crystal structure of Pseudooceanicola lipolyticus Argonaute bound to 5' OH guide DNA · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A2M8J4C7
Elsewhere: RCSB PDB 7R8G · PDBe 7R8G · UniProt A0A2M8J4C7

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