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Crystal structure of human arc ctd in complex with two anti-arc nanobodies

Analyse Crystal structure of human arc ctd in complex with two anti-arc nanobodies in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7R23
Type: protein
Length: 388 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Arc; Chains: B; Chains: C
UniProt: A0A3L7I2Q1
Pockets: 3 · best druggability 0.50

Structure

x-ray diffraction · 3 distinct chains · 30% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Arc	protein	145	69% helix, 0% strand	A0A3L7I2Q1
B	Chains: B	protein	124	7% helix, 44% strand	—
C	Chains: C	protein	119	5% helix, 52% strand	—

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	259	0.50	0.74	27	empty
2	72	0.36	0.77	15	empty
3	80	0.35	0.76	18	empty

Interfaces

2 interfaces between chains.

A–B · 1056 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 847 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7R23 · Crystal structure of human Arc CTD in complex with two anti-Arc nanobodies · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A3L7I2Q1
Elsewhere: RCSB PDB 7R23 · PDBe 7R23 · UniProt A0A3L7I2Q1

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