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Structure of native, iodinated bovine thyroglobulin solved on strepavidin affinity grids.
Analyse Structure of native, iodinated bovine thyroglobulin solved on strepavidin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QTQ
- Type
- protein
- Length
- 3,577 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thyroglobulin
- UniProt
- P01267
- Ligands
- T44, NAG, MAN
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 2 distinct chains · 28% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thyroglobulin | protein | 1789 | 28% helix, 16% strand | P01267 |
| B | Thyroglobulin | protein | 1788 | 28% helix, 15% strand | P01267 |
Ligands and binding sites
- T44 · 3,5,3',5'-tetraiodo-L-thyronine · ligand · 2 copies · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 20 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 949 | 0.86 | 0.88 | 90 | empty |
| 2 | 1140 | 0.85 | 0.86 | 119 | empty |
| 3 | 1015 | 0.79 | 0.81 | 112 | empty |
| 4 | 876 | 0.79 | 0.82 | 82 | empty |
| 5 | 521 | 0.76 | 0.84 | 52 | empty |
Interfaces
1 interface between chains.
- A–B · 8137 Ų buried · 59 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 78 disulfide, 16 glycan, 4 covalent, 2 modified (disulfide, N-glycosylation, covalent ligand, nonstandard).
Compared structures
- 7QTQ · Structure of Native, iodinated bovine thyroglobulin solved on strepavidin affinity grids. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01267
- Elsewhere: RCSB PDB 7QTQ · PDBe 7QTQ · UniProt P01267
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