Research workbench
Structural basis on the interaction of scribble PDZ domains with the tick born encephalitis virus (tbev) NS5 protein
Analyse Structural basis on the interaction of scribble PDZ domains with the tick born… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QS9
- Type
- protein
- Length
- 192 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein scribble homolog; RNA-directed RNA polymerase NS5
- EC
- 2.1.1.56, 2.1.1.57, 2.7.7.48
- UniProt
- Q14160, Q01299
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 3 distinct chains · 14% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein scribble homolog | protein | 92 | 14% helix, 41% strand | Q14160 |
| B | Protein scribble homolog | protein | 90 | 16% helix, 42% strand | Q14160 |
| C, E | RNA-directed RNA polymerase NS5 (EC 2.1.1.56, 2.1.1.57, 2.7.7.48) | protein | 5 | 0% helix, 60% strand | Q01299 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.40 | 0.78 | 15 | empty |
| 2 | 50 | 0.25 | 0.73 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 466 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 410 Ų buried · 10 hydrogen bonds · protein-protein
- B–E · 408 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7QS9 · Structural basis on the interaction of Scribble PDZ domains with the Tick Born… · the same entry in another collection · chain A against A, TM-score 1.00
- Q14160 · AlphaFold monomer V2.0 prediction for protein scribble homolog (Q14160) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14160
- Every structure of UniProt Q01299
- Elsewhere: RCSB PDB 7QS9 · PDBe 7QS9 · UniProt Q14160 · UniProt Q01299
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