Research workbench
Crystal structure of B30.2 pryspry domain of TRIM36
Analyse Crystal structure of B30.2 pryspry domain of TRIM36 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QS4
- Type
- protein
- Length
- 760 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Haprin-A2
- UniProt
- Q4R1Q4
- Pockets
- 11 · best druggability 0.84
Structure
x-ray diffraction · 4 distinct chains · 12% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Haprin-A2 | protein | 206 | 15% helix, 39% strand | Q4R1Q4 |
| B | Haprin-A2 | protein | 195 | 12% helix, 42% strand | Q4R1Q4 |
| C | Haprin-A2 | protein | 182 | 11% helix, 44% strand | Q4R1Q4 |
| D | Haprin-A2 | protein | 177 | 8% helix, 46% strand | Q4R1Q4 |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 686 | 0.84 | 0.88 | 101 | empty |
| 2 | 54 | 0.51 | 0.87 | 15 | empty |
| 3 | 157 | 0.51 | 0.79 | 33 | empty |
| 4 | 102 | 0.49 | 0.81 | 25 | empty |
| 5 | 54 | 0.47 | 0.85 | 17 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1986 Ų buried · 28 hydrogen bonds · protein-protein
- A–B · 1885 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 931 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 568 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 446 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7QS4 · Crystal structure of B30.2 PRYSPRY domain of TRIM36 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4R1Q4
- Elsewhere: RCSB PDB 7QS4 · PDBe 7QS4 · UniProt Q4R1Q4
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