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Structure of the post-fusion complex between precursor membrane ectodomain (prm) and envelope ectodomain protein (E) from tick-borne encephalitis virus
Analyse Structure of the post-fusion complex between precursor membrane ectodomain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QRG
- Type
- protein
- Length
- 479 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Envelope protein E; Genome polyprotein
- UniProt
- P14336
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Envelope protein E | protein | 399 | 9% helix, 48% strand | P14336 |
| D | Genome polyprotein | protein | 80 | 4% helix, 44% strand | P14336 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 296 | 0.56 | 0.76 | 45 | GOL |
| 2 | 132 | 0.50 | 0.80 | 27 | empty |
| 3 | 216 | 0.49 | 0.75 | 39 | empty |
| 4 | 65 | 0.28 | 0.73 | 15 | GOL |
Interfaces
1 interface between chains.
- A–D · 853 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 7QRG · Structure of the post-fusion complex between precursor membrane ectodomain (prM) and… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14336
- Elsewhere: RCSB PDB 7QRG · PDBe 7QRG · UniProt P14336
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