Research workbench
Human rzz kinetochore corona complex.
Analyse Human rzz kinetochore corona complex. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QPG
- Type
- protein
- Length
- 7,156 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein zwilch homolog; Kinetochore-associated protein 1; CENTROMERE/KINETOCHORE protein…
- UniProt
- Q9H900, P50748, O43264
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 3 distinct chains · 56% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, C | Protein zwilch homolog | protein | 591 | 35% helix, 17% strand | Q9H900 |
| R, S | Kinetochore-associated protein 1 | protein | 2208 | 58% helix, 9% strand | P50748 |
| W, X | CENTROMERE/KINETOCHORE protein ZW10 homolog | protein | 779 | 65% helix, 4% strand | O43264 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 991 | 0.82 | 0.83 | 90 | empty |
| 2 | 802 | 0.80 | 0.83 | 68 | empty |
| 3 | 1028 | 0.79 | 0.80 | 89 | empty |
| 4 | 1055 | 0.79 | 0.80 | 91 | empty |
| 5 | 944 | 0.79 | 0.81 | 93 | empty |
Interfaces
12 interfaces between chains.
- R–W · 5542 Ų buried · 33 hydrogen bonds · protein-protein
- S–X · 5488 Ų buried · 32 hydrogen bonds · protein-protein
- R–S · 5322 Ų buried · 44 hydrogen bonds · protein-protein
- B–R · 2106 Ų buried · 10 hydrogen bonds · protein-protein
- C–S · 1984 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 7QPG · Human RZZ kinetochore corona complex. · the same entry in another collection · chain R against R, TM-score 1.00
- Q9H900 · AlphaFold monomer V2.0 prediction for protein zwilch homolog (Q9H900) · a predicted model of the same protein · chain B against A, TM-score 0.96
- O43264 · AlphaFold monomer V2.0 prediction for CENTROMERE/KINETOCHORE protein ZW10 homolog (O43264) · a predicted model of the same protein · chain W against A, TM-score 0.61
- P50748 · AlphaFold monomer V2.0 prediction for kinetochore-associated protein 1 (P50748) · a predicted model of the same protein · chain R against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H900
- Every structure of UniProt P50748
- Every structure of UniProt O43264
- Elsewhere: RCSB PDB 7QPG · PDBe 7QPG · UniProt Q9H900 · UniProt P50748 · UniProt O43264
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