Research workbench

Inward-facing npa bound form of auxin transporter PIN8

Analyse Inward-facing npa bound form of auxin transporter PIN8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7QPC
Type: protein
Length: 654 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Auxin efflux carrier component 8
UniProt: Q9LFP6
Ligands: E7O, DLP
Pockets: 9 · best druggability 0.75

Structure

electron microscopy · 1 distinct chain · 77% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Auxin efflux carrier component 8	protein	327	77% helix, 1% strand	Q9LFP6

Ligands and binding sites

E7O · 2-(naphthalen-1-ylcarbamoyl)benzoic acid · ligand · 2 copies · chains A, B
DLP · 1,2-dilinoleoyl-sn-glycero-3-phosphocholine · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	484	0.75	0.83	48	E7O
2	466	0.75	0.83	44	E7O
3	110	0.65	0.88	18	empty
4	135	0.61	0.85	21	empty
5	280	0.53	0.75	29	empty

Interfaces

1 interface between chains.

A–B · 1522 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

7QPC · Inward-facing NPA bound form of auxin transporter PIN8 · the same entry in another collection · chain A against A, TM-score 1.00
Q9LFP6 · AlphaFold monomer V2.0 prediction for auxin efflux carrier component 8 (Q9LFP6) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9LFP6
Elsewhere: RCSB PDB 7QPC · PDBe 7QPC · UniProt Q9LFP6

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