Research workbench
Structure of recombinant human gamma-tubulin ring complex 4-spoked assembly intermediate (spokes 9-12)
Analyse Structure of recombinant human gamma-tubulin ring complex 4-spoked assembly… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QJE
- Type
- protein
- Length
- 3,863 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-tubulin complex component 4; Gamma-tubulin complex component 5; Gamma-tubulin…
- UniProt
- Q9UGJ1, Q96RT8, Q96RT7, P23258
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 5 distinct chains · 59% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| I | Gamma-tubulin complex component 4 | protein | 521 | 65% helix, 1% strand | Q9UGJ1 |
| J | Gamma-tubulin complex component 5 | protein | 534 | 64% helix, 1% strand | Q96RT8 |
| K | Gamma-tubulin complex component 4 | protein | 562 | 61% helix, 1% strand | Q9UGJ1 |
| L | Gamma-tubulin complex component 6 | protein | 566 | 59% helix, 1% strand | Q96RT7 |
| W, X, Y, Z | Tubulin gamma-1 chain | protein | 420 | 42% helix, 18% strand | P23258 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 305 | 0.83 | 0.93 | 31 | empty |
| 2 | 965 | 0.81 | 0.82 | 81 | empty |
| 3 | 142 | 0.78 | 0.95 | 30 | empty |
| 4 | 394 | 0.78 | 0.87 | 46 | empty |
| 5 | 948 | 0.76 | 0.79 | 106 | empty |
Interfaces
15 interfaces between chains.
- K–L · 2387 Ų buried · 25 hydrogen bonds · protein-protein
- L–Z · 2291 Ų buried · 27 hydrogen bonds · protein-protein
- K–Y · 2127 Ų buried · 26 hydrogen bonds · protein-protein
- I–W · 2106 Ų buried · 11 hydrogen bonds · protein-protein
- J–L · 1675 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 7QJE · Structure of recombinant human gamma-Tubulin Ring Complex 4-spoked assembly intermediate… · the same entry in another collection · chain X against X, TM-score 1.00
- P23258 · AlphaFold monomer V2.0 prediction for tubulin gamma-1 chain (P23258) · a predicted model of the same protein · chain W against A, TM-score 0.95
- Q96RT8 · AlphaFold monomer V2.0 prediction for gamma-tubulin complex component 5 (Q96RT8) · a predicted model of the same protein · chain J against A, TM-score 0.94
- Q9UGJ1 · AlphaFold monomer V2.0 prediction for gamma-tubulin complex component 4 (Q9UGJ1) · a predicted model of the same protein · chain I against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UGJ1
- Every structure of UniProt Q96RT8
- Every structure of UniProt Q96RT7
- Every structure of UniProt P23258
- Elsewhere: RCSB PDB 7QJE · PDBe 7QJE · UniProt Q9UGJ1 · UniProt Q96RT8 · UniProt Q96RT7 · UniProt P23258
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