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Magic-angle spinning NMR structure of the human voltage-dependent anion channel 1 (E73V/C127A/C232S) in dmpc lipid bilayers

Analyse Magic-angle spinning NMR structure of the human voltage-dependent anion channel… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7QI2
Type: protein
Length: 283 residues
Chains: 1
Method: solid-state nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Voltage-dependent anion-selective channel protein 1
UniProt: P21796
Pockets: 3 · best druggability 0.75

Structure

solid-state nmr · 1 distinct chain · 4% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Voltage-dependent anion-selective channel protein 1	protein	283	4% helix, 53% strand	P21796

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1158	0.75	0.78	102	empty
2	305	0.58	0.77	42	empty
3	72	0.42	0.81	17	empty

Compared structures

7QI2 · Magic-angle spinning NMR structure of the human voltage-dependent anion channel 1… · the same entry in another collection · chain A against A, TM-score 1.00
P21796 · AlphaFold monomer V2.0 prediction for voltage-dependent anion- selective channel protein… · a predicted model of the same protein · chain A against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21796
Elsewhere: RCSB PDB 7QI2 · PDBe 7QI2 · UniProt P21796

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