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Brxr, a wyl-domain containing transcriptional regulator

Analyse Brxr, a wyl-domain containing transcriptional regulator in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7QFZ
Type: protein
Length: 2,276 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wyl domain-containing protein
UniProt: B7L3Y3
Ligands: SO4
Pockets: 20 · best druggability 0.81

Structure

x-ray diffraction · 7 distinct chains · 34% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Wyl domain-containing protein	protein	287	34% helix, 25% strand	B7L3Y3
B, F	Wyl domain-containing protein	protein	288	33% helix, 25% strand	B7L3Y3
C	Wyl domain-containing protein	protein	289	34% helix, 25% strand	B7L3Y3
D	Wyl domain-containing protein	protein	290	34% helix, 24% strand	B7L3Y3
E	Wyl domain-containing protein	protein	286	34% helix, 26% strand	B7L3Y3
G	Wyl domain-containing protein	protein	282	35% helix, 26% strand	B7L3Y3
H	Wyl domain-containing protein	protein	266	35% helix, 27% strand	B7L3Y3

Ligands and binding sites

SO4 · Sulfate ion · ion · 16 copies · chains A, B, C, D, E, F, G, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	887	0.81	0.83	100	SO4
2	507	0.75	0.83	85	SO4
3	127	0.74	0.93	34	empty
4	478	0.73	0.83	56	SO4
5	704	0.73	0.79	79	SO4

Interfaces

12 interfaces between chains.

E–F · 4875 Å² buried · 90 hydrogen bonds · protein-protein
C–D · 4804 Å² buried · 82 hydrogen bonds · protein-protein
A–B · 4742 Å² buried · 84 hydrogen bonds · protein-protein
G–H · 4639 Å² buried · 77 hydrogen bonds · protein-protein
A–D · 526 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

7QFZ · BrxR, a WYL-domain containing transcriptional regulator · the same entry in another collection · chain F against F, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B7L3Y3
Elsewhere: RCSB PDB 7QFZ · PDBe 7QFZ · UniProt B7L3Y3

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