Research workbench
80S-bound human ski complex in the open state
Analyse 80S-bound human ski complex in the open state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QE0
- Type
- protein + RNA
- Length
- 958 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Helicase SKI2W; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')
- EC
- 3.6.4.-
- UniProt
- Q15477
- Pockets
- 11 · best druggability 0.85
Structure
electron microscopy · 2 distinct chains · 47% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Helicase SKI2W (EC 3.6.4.-) | protein | 949 | 47% helix, 11% strand | Q15477 |
| E | RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') | rna | 9 | — | — |
Pockets
11 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1148 | 0.85 | 0.86 | 110 | empty |
| 2 | 1137 | 0.80 | 0.81 | 100 | empty |
| 3 | 133 | 0.77 | 0.95 | 34 | empty |
| 4 | 626 | 0.71 | 0.79 | 61 | empty |
| 5 | 84 | 0.70 | 0.93 | 20 | empty |
Interfaces
1 interface between chains.
- A–E · 1297 Ų buried · 32 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15477
- Elsewhere: RCSB PDB 7QE0 · PDBe 7QE0 · UniProt Q15477
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