Research workbench
Crystal structure of S. cerevisiae SSO2 in complex with the pleckstrin homology domain of SEC3
Analyse Crystal structure of S. cerevisiae SSO2 in complex with the pleckstrin homology… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7Q83
- Type
- protein
- Length
- 658 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Exocyst complex component SEC3; Protein SSO2
- UniProt
- P33332, P39926
- Pockets
- 13 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 64% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Exocyst complex component SEC3 | protein | 175 | 30% helix, 35% strand | P33332 |
| B | Protein SSO2 | protein | 152 | 85% helix, 0% strand | P39926 |
| D | Protein SSO2 | protein | 156 | 83% helix, 0% strand | P39926 |
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 424 | 0.77 | 0.86 | 59 | empty |
| 2 | 461 | 0.64 | 0.77 | 39 | empty |
| 3 | 402 | 0.61 | 0.76 | 34 | empty |
| 4 | 70 | 0.53 | 0.86 | 14 | empty |
| 5 | 142 | 0.45 | 0.77 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1137 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1116 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 858 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7Q83 · Crystal structure of S. cerevisiae Sso2 in complex with the pleckstrin homology domain of… · the same entry in another collection · chain A against A, TM-score 1.00
- P33332 · AlphaFold monomer V2.0 prediction for exocyst complex component SEC3 (P33332) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P39926 · AlphaFold monomer V2.0 prediction for protein SSO2 (P39926) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33332
- Every structure of UniProt P39926
- Elsewhere: RCSB PDB 7Q83 · PDBe 7Q83 · UniProt P33332 · UniProt P39926
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