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The solution structure of HSDND1 RRM12 bound to cuuauuug RNA

Analyse The solution structure of HSDND1 RRM12 bound to cuuauuug RNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7Q4L
Type: protein + RNA
Length: 235 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dead end protein homolog 1; RNA (5'-R(*CP*UP*UP*AP*UP*UP*UP*G)-3')
UniProt: Q8IYX4
Pockets: 4 · best druggability 0.61

Structure

solution nmr · 2 distinct chains · 33% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dead end protein homolog 1	protein	227	33% helix, 22% strand	Q8IYX4
B	RNA (5'-R(CPUPUPAPUPUPUPG)-3')	rna	8	—	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.61	0.92	18	empty
2	174	0.45	0.75	25	empty
3	75	0.34	0.76	17	empty
4	64	0.31	0.75	19	empty

Interfaces

1 interface between chains.

A–B · 981 Å² buried · 21 hydrogen bonds · protein-nucleic

Compared structures

7Q4L · The solution structure of hsDND1 RRM12 bound to CUUAUUUG RNA · the same entry in another collection · chain B against B, TM-score 1.00
Q8IYX4 · AlphaFold monomer V2.0 prediction for dead end protein homolog 1 (Q8IYX4) · a predicted model of the same protein · chain A against A, TM-score 0.66

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IYX4
Elsewhere: RCSB PDB 7Q4L · PDBe 7Q4L · UniProt Q8IYX4

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