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Crystal structure of human sting in complex with 3'3'-C-(2'F,2'DA- ISONUCA)MP

Analyse Crystal structure of human sting in complex with 3'3'-C-(2'F,2'DA- ISONUCA)MP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7Q3B
Type: protein
Length: 176 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Stimulator of interferon protein
UniProt: A0A2R3XZB7
Ligands: 8SC
Pockets: 1 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Stimulator of interferon protein	protein	176	43% helix, 26% strand	A0A2R3XZB7

Ligands and binding sites

8SC · 3'3'-c-(2'F,2'dA-isonucA)MP · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	136	0.40	0.74	20	empty

Compared structures

7Q3B · Crystal structure of human STING in complex with 3'3'-c-(2'F,2'dA-isonucA)MP · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A2R3XZB7
Elsewhere: RCSB PDB 7Q3B · PDBe 7Q3B · UniProt A0A2R3XZB7

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