Research workbench
Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides
Analyse Pancreatic spasmolytic polypeptide: first three-dimensional structure of a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1PSP
- Type
- protein
- Length
- 212 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pancreatic spasmolytic polypeptide
- UniProt
- P01359
- Pockets
- 2 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 24% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Pancreatic spasmolytic polypeptide | protein | 106 | 24% helix, 9% strand | P01359 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 248 | 0.58 | 0.79 | 25 | empty |
| 2 | 241 | 0.57 | 0.78 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 551 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 14 disulfide, 2 modified (disulfide, cyclization).
Compared structures
- 1PSP · Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the… · the same entry in another collection · chain A against A, TM-score 1.00
- P01359 · AlphaFold monomer V2.0 prediction for trefoil factor 2 (P01359) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01359
- Elsewhere: RCSB PDB 1PSP · PDBe 1PSP · UniProt P01359
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