Research workbench
Hbc-F97L (premature secretion phenotype) in complex with triton X-100
Analyse Hbc-F97L (premature secretion phenotype) in complex with triton X-100 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PZI
- Type
- protein
- Length
- 572 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Capsid protein
- UniProt
- P03146
- Ligands
- TRT
- Pockets
- 8 · best druggability 0.78
Structure
electron microscopy · 1 distinct chain · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, C, D | Capsid protein | protein | 143 | 69% helix, 0% strand | P03146 |
Ligands and binding sites
- TRT · Fragment of triton X-100 · ligand · 4 copies · chains B, A, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 169 | 0.78 | 0.94 | 28 | empty |
| 2 | 184 | 0.71 | 0.88 | 24 | TRT |
| 3 | 181 | 0.71 | 0.88 | 21 | TRT |
| 4 | 201 | 0.70 | 0.87 | 25 | TRT |
| 5 | 188 | 0.69 | 0.87 | 25 | TRT |
Interfaces
4 interfaces between chains.
- B–A · 2053 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 2009 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 686 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 11 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7PZI · HBc-F97L (premature secretion phenotype) in complex with Triton X-100 · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03146
- Elsewhere: RCSB PDB 7PZI · PDBe 7PZI · UniProt P03146
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