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Delta-latroinsectotoxin dimer

Analyse Delta-latroinsectotoxin dimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7PTY
Type
protein
Length
1,715 residues
Chains
2
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Delta-latroinsectotoxin-LT1A
UniProt
Q25338
Pockets
20 · best druggability 0.85

Structure

electron microscopy · 2 distinct chains · 56% helix, 2% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADelta-latroinsectotoxin-LT1Aprotein85056% helix, 3% strandQ25338
BDelta-latroinsectotoxin-LT1Aprotein86555% helix, 2% strandQ25338

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
19730.850.85103empty
24880.810.8878empty
31730.770.9333empty
44950.760.8464empty
53350.750.8661empty

Interfaces

1 interface between chains.

  • A–B · 938 Ų buried · 10 hydrogen bonds · protein-protein

Compared structures

  • 7PTY · Delta-latroinsectotoxin dimer · the same entry in another collection · chain A against A, TM-score 1.00
  • Q25338 · AlphaFold monomer V2.0 prediction for delta-latroinsectotoxin-LT1A (Q25338) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

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