Research workbench
HSPEPT2 bound to ala-phe in the inward facing partially occluded conformation
Analyse HSPEPT2 bound to ala-phe in the inward facing partially occluded conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PMY
- Type
- protein
- Length
- 659 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Solute carrier family 15 member 2; Ala-phe
- UniProt
- Q16348
- Pockets
- 7 · best druggability 0.76
Structure
electron microscopy · 2 distinct chains · 56% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Solute carrier family 15 member 2 | protein | 657 | 56% helix, 18% strand | Q16348 |
| B | Ala-phe | protein | 2 | 0% helix, 0% strand | — |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 83 | 0.76 | 0.99 | 22 | empty |
| 2 | 366 | 0.76 | 0.86 | 41 | empty |
| 3 | 671 | 0.75 | 0.81 | 74 | empty |
| 4 | 219 | 0.52 | 0.76 | 20 | empty |
| 5 | 170 | 0.48 | 0.76 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 297 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7PMY · HsPepT2 bound to Ala-Phe in the inward facing partially occluded conformation · the same entry in another collection · chain A against A, TM-score 1.00
- Q16348 · AlphaFold monomer V2.0 prediction for solute carrier family 15 member 2 (Q16348) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16348
- Elsewhere: RCSB PDB 7PMY · PDBe 7PMY · UniProt Q16348
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