Research workbench
Partial structure of tyrosine hydroxylase lacking the first 35 residues in complex with dopamine.
Analyse Partial structure of tyrosine hydroxylase lacking the first 35 residues in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PIM
- Type
- protein
- Length
- 1,412 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine 3-monooxygenase; Regulatory domain alpha-helix
- EC
- 1.14.16.2
- UniProt
- P07101
- Ligands
- LDP, FE
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 2 distinct chains · 54% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, D, F | Tyrosine 3-monooxygenase (EC 1.14.16.2) | protein | 335 | 53% helix, 11% strand | P07101 |
| G, C, E, H | Regulatory domain alpha-helix | protein | 18 | 89% helix, 0% strand | — |
Ligands and binding sites
- LDP · L-dopamine · ligand · 4 copies · chains B, G, A, C, D, E, F, H
- FE · Fe (III) ion · metal · 4 copies · chains B, A, D, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 999 | 0.87 | 0.88 | 111 | empty |
| 2 | 993 | 0.87 | 0.88 | 109 | empty |
| 3 | 697 | 0.84 | 0.88 | 63 | empty |
| 4 | 807 | 0.81 | 0.84 | 71 | empty |
| 5 | 749 | 0.81 | 0.85 | 53 | LDP |
Interfaces
10 interfaces between chains.
- B–A · 1918 Ų buried · 20 hydrogen bonds · protein-protein
- D–F · 1916 Ų buried · 20 hydrogen bonds · protein-protein
- B–D · 619 Ų buried · 2 hydrogen bonds · protein-protein
- A–F · 617 Ų buried · 2 hydrogen bonds · protein-protein
- B–G · 546 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7PIM · Partial structure of tyrosine hydroxylase lacking the first 35 residues in complex with… · the same entry in another collection · chain H against H, TM-score 1.00
- P07101 · AlphaFold monomer V2.0 prediction for tyrosine 3-monooxygenase (P07101) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07101
- Elsewhere: RCSB PDB 7PIM · PDBe 7PIM · UniProt P07101
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