Research workbench
Human voltage-gated potassium channel KV3.1 (with edta)
Analyse Human voltage-gated potassium channel KV3.1 (with edta) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PHL
- Type
- protein
- Length
- 1,564 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel, shaw-related subfamily, member 1
- UniProt
- Q3KNS8
- Ligands
- PCF, ZN, K
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 64% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, B, D | Potassium voltage-gated channel, shaw-related subfamily, member 1 | protein | 391 | 64% helix, 5% strand | Q3KNS8 |
Ligands and binding sites
- PCF · 1,2-diacyl-sn-glycero-3-phoshocholine · ligand · 8 copies · chains A, C, B, D
- ZN · Zinc ion · metal · 4 copies · chains A, B, C, D
- K · Potassium ion · metal · 4 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1109 | 0.83 | 0.84 | 65 | empty |
| 2 | 816 | 0.82 | 0.85 | 51 | empty |
| 3 | 617 | 0.69 | 0.77 | 73 | empty |
| 4 | 330 | 0.65 | 0.80 | 45 | empty |
| 5 | 200 | 0.62 | 0.82 | 30 | empty |
Interfaces
6 interfaces between chains.
- A–D · 3071 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 3060 Ų buried · 18 hydrogen bonds · protein-protein
- C–B · 3055 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 3043 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 37 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7PHL · Human voltage-gated potassium channel Kv3.1 (with EDTA) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3KNS8
- Elsewhere: RCSB PDB 7PHL · PDBe 7PHL · UniProt Q3KNS8
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