Research workbench
Human voltage-gated potassium channel KV3.1 in dimeric state (with zn)
Analyse Human voltage-gated potassium channel KV3.1 in dimeric state (with zn) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PHK
- Type
- protein
- Length
- 3,140 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel, shaw-related subfamily, member 1
- UniProt
- Q3KNS8
- Ligands
- PCF, ZN, K
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 2 distinct chains · 62% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, B, D | Potassium voltage-gated channel, shaw-related subfamily, member 1 | protein | 392 | 63% helix, 7% strand | Q3KNS8 |
| E, G, F, H | Potassium voltage-gated channel, shaw-related subfamily, member 1 | protein | 393 | 62% helix, 7% strand | Q3KNS8 |
Ligands and binding sites
- PCF · 1,2-diacyl-sn-glycero-3-phoshocholine · ligand · 16 copies · chains A, C, B, D, E, G, F, H
- ZN · Zinc ion · metal · 8 copies · chains A, B, C, D, E, F, G, H
- K · Potassium ion · metal · 8 copies · chains A, C, B, D, E, G, F, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 821 | 0.84 | 0.85 | 56 | empty |
| 2 | 820 | 0.83 | 0.85 | 58 | empty |
| 3 | 949 | 0.81 | 0.83 | 70 | empty |
| 4 | 847 | 0.81 | 0.84 | 56 | empty |
| 5 | 657 | 0.75 | 0.81 | 89 | empty |
Interfaces
16 interfaces between chains.
- G–H · 3042 Ų buried · 17 hydrogen bonds · protein-protein
- E–F · 3035 Ų buried · 17 hydrogen bonds · protein-protein
- C–B · 3035 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 3028 Ų buried · 19 hydrogen bonds · protein-protein
- G–F · 3024 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 7PHK · Human voltage-gated potassium channel Kv3.1 in dimeric state (with Zn) · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3KNS8
- Elsewhere: RCSB PDB 7PHK · PDBe 7PHK · UniProt Q3KNS8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.