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Ligand binding domain of the human peroxisome proliferator activated receptor gamma

Analyse Ligand binding domain of the human peroxisome proliferator activated receptor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1PRG
Type: protein
Length: 540 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (peroxisome proliferator activated receptor gamma)
UniProt: P37231
Pockets: 9 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 64% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protein (peroxisome proliferator activated receptor gamma)	protein	270	64% helix, 5% strand	P37231

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	467	0.84	0.91	51	empty
2	435	0.77	0.86	43	empty
3	90	0.76	0.97	22	empty
4	393	0.68	0.81	35	empty
5	271	0.64	0.81	19	empty

Interfaces

1 interface between chains.

A–B · 925 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

1PRG · Ligand binding domain of the human peroxisome proliferator activated receptor gamma · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37231
Elsewhere: RCSB PDB 1PRG · PDBe 1PRG · UniProt P37231

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