Research workbench

Human L-xylulose reductase holoenzyme

Analyse Human L-xylulose reductase holoenzyme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1PR9
Type: protein
Length: 488 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: L-xylulose reductase
EC: 1.1.1.10
UniProt: Q7Z4W1
Ligands: NAP, K, 2HP
Pockets: 6 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	L-xylulose reductase (EC 1.1.1.10)	protein	244	49% helix, 17% strand	Q7Z4W1

Ligands and binding sites

NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
K · Potassium ion · metal · 2 copies · chains A, B
2HP · Dihydrogenphosphate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	392	0.77	0.86	45	K, NAP, 2HP
2	408	0.77	0.86	45	K, NAP, 2HP
3	131	0.42	0.75	17	empty
4	110	0.40	0.76	19	empty
5	69	0.30	0.74	12	empty

Interfaces

1 interface between chains.

A–B · 294 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1PR9 · Human L-Xylulose Reductase Holoenzyme · the same entry in another collection · chain A against A, TM-score 1.00
Q7Z4W1 · AlphaFold monomer V2.0 prediction for L-xylulose reductase (Q7Z4W1) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7Z4W1
Elsewhere: RCSB PDB 1PR9 · PDBe 1PR9 · UniProt Q7Z4W1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.