Research workbench
Model of the inner ring of the human nuclear pore complex
Analyse Model of the inner ring of the human nuclear pore complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PER
- Type
- protein
- Length
- 13,520 residues
- Chains
- 24
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin P54; Nucleoporin P58/P45; Nuclear pore glycoprotein P62; Nuclear pore complex…
- UniProt
- Q7Z3B4, Q9BVL2, P37198, Q92621, O75694, Q8N1F7
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 6 distinct chains · 62% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F, X, L, R | Nucleoporin P54 | protein | 335 | 63% helix, 12% strand | Q7Z3B4 |
| G, Y, M, S | Nucleoporin P58/P45 | protein | 171 | 86% helix, 0% strand | Q9BVL2 |
| H, Z, N, T | Nuclear pore glycoprotein P62 | protein | 169 | 85% helix, 0% strand | P37198 |
| P, V, D, J | Nuclear pore complex protein NUP205 | protein | 1028 | 74% helix, 1% strand | Q92621 |
| W, K, E, Q | Nuclear pore complex protein NUP155 | protein | 1083 | 46% helix, 16% strand | O75694 |
| C, I, O, U | Nuclear pore complex protein NUP93 | protein | 594 | 59% helix, 1% strand | Q8N1F7 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1070 | 0.81 | 0.82 | 158 | empty |
| 2 | 1096 | 0.81 | 0.82 | 129 | empty |
| 3 | 819 | 0.81 | 0.84 | 135 | empty |
| 4 | 803 | 0.80 | 0.83 | 105 | empty |
| 5 | 777 | 0.79 | 0.83 | 110 | empty |
Interfaces
33 interfaces between chains.
- V–W · 2312 Ų buried · 144 hydrogen bonds · protein-protein
- P–O · 1723 Ų buried · 128 hydrogen bonds · protein-protein
- F–H · 786 Ų buried · 0 hydrogen bonds · protein-protein
- L–N · 785 Ų buried · 0 hydrogen bonds · protein-protein
- R–T · 784 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7PER · Model of the inner ring of the human nuclear pore complex · the same entry in another collection · chain S against S, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z3B4
- Every structure of UniProt Q9BVL2
- Every structure of UniProt P37198
- Every structure of UniProt Q92621
- Every structure of UniProt O75694
- Every structure of UniProt Q8N1F7
- Elsewhere: RCSB PDB 7PER · PDBe 7PER · UniProt Q7Z3B4 · UniProt Q9BVL2 · UniProt P37198 · UniProt Q92621 · UniProt O75694 · UniProt Q8N1F7
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