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Pre-catalytic complex of 10-23 dnazyme with RNA target

Analyse Pre-catalytic complex of 10-23 dnazyme with RNA target in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7PDU
Type
DNA + RNA
Length
52 nucleotides
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
10-23 dnazyme (33-mer); RNA target (19-mer)
Pockets
2 · best druggability 0.44

Structure

solution nmr · 2 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A10-23 dnazyme (33-mer)dna33——
BRNA target (19-mer)rna19——

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11940.440.7516empty
2500.300.7712empty

Interfaces

1 interface between chains.

  • A–B · 1474 Ų buried · 135 hydrogen bonds · nucleic-nucleic

Compared structures

  • 7PDU · Pre-catalytic complex of 10-23 DNAzyme with RNA target · the same entry in another collection · chain A against A, TM-score 1.00

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