Research workbench
Structure of adenylyl cyclase 9 in complex with darpin C4 and ATP-as
Analyse Structure of adenylyl cyclase 9 in complex with darpin C4 and ATP-as in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PDH
- Type
- protein
- Length
- 577 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylate cyclase 9; Darpin C4
- UniProt
- E1BM79
- Pockets
- 10 · best druggability 0.86
Structure
electron microscopy · 2 distinct chains · 42% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylate cyclase 9 | protein | 449 | 39% helix, 26% strand | E1BM79 |
| B | Darpin C4 | protein | 128 | 53% helix, 0% strand | — |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1039 | 0.86 | 0.87 | 141 | empty |
| 2 | 55 | 0.68 | 0.96 | 14 | empty |
| 3 | 55 | 0.68 | 0.96 | 21 | empty |
| 4 | 131 | 0.65 | 0.87 | 21 | empty |
| 5 | 192 | 0.53 | 0.78 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 586 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7PDH · structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E1BM79
- Elsewhere: RCSB PDB 7PDH · PDBe 7PDH · UniProt E1BM79
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