Research workbench
Structure of the heterotetrameric sdr family member bbscd
Analyse Structure of the heterotetrameric sdr family member bbscd in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PCS
- Type
- protein
- Length
- 982 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bbsc; Bbsd
- UniProt
- Q9KJF2, Q9KJF1
- Ligands
- NAD
- Pockets
- 7 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Bbsc | protein | 244 | 52% helix, 17% strand | Q9KJF2 |
| B, D | Bbsd | protein | 247 | 53% helix, 16% strand | Q9KJF1 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 2 copies · chains B, D
- GOL · Glycerol · additive · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 584 | 0.65 | 0.75 | 50 | NAD, GOL |
| 2 | 559 | 0.64 | 0.75 | 51 | NAD, GOL |
| 3 | 377 | 0.55 | 0.74 | 45 | empty |
| 4 | 364 | 0.54 | 0.74 | 43 | GOL |
| 5 | 188 | 0.48 | 0.75 | 23 | empty |
Interfaces
6 interfaces between chains.
- A–C · 1831 Ų buried · 32 hydrogen bonds · protein-protein
- C–D · 1713 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1711 Ų buried · 25 hydrogen bonds · protein-protein
- B–D · 1579 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 367 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7PCS · Structure of the heterotetrameric SDR family member BbsCD · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9KJF2
- Every structure of UniProt Q9KJF1
- Elsewhere: RCSB PDB 7PCS · PDBe 7PCS · UniProt Q9KJF2 · UniProt Q9KJF1
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