Research workbench
Varicella zoster ORF24-ORF27 nuclear egress complex
Analyse Varicella zoster ORF24-ORF27 nuclear egress complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PAB
- Type
- protein
- Length
- 821 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear egress protein 2,NUCLEAR egress protein 1
- UniProt
- Q6QCN1, Q6QCM8
- Ligands
- ZN, SO4
- Pockets
- 13 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear egress protein 2,NUCLEAR egress protein 1 | protein | 415 | 38% helix, 27% strand | Q6QCN1, Q6QCM8 |
| C | Nuclear egress protein 2,NUCLEAR egress protein 1 | protein | 406 | 37% helix, 25% strand | Q6QCN1, Q6QCM8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 74 | 0.57 | 0.88 | 28 | empty |
| 2 | 296 | 0.54 | 0.75 | 22 | empty |
| 3 | 239 | 0.51 | 0.76 | 22 | empty |
| 4 | 59 | 0.43 | 0.82 | 15 | empty |
| 5 | 143 | 0.41 | 0.74 | 26 | empty |
Interfaces
1 interface between chains.
- A–C · 838 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 7PAB · Varicella zoster Orf24-Orf27 nuclear egress complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6QCN1
- Every structure of UniProt Q6QCM8
- Elsewhere: RCSB PDB 7PAB · PDBe 7PAB · UniProt Q6QCN1 · UniProt Q6QCM8
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