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Structure of human ASCT1 transporter

Analyse Structure of human ASCT1 transporter in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7P4I
Type: protein
Length: 1,284 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neutral amino acid transporter a
UniProt: P43007
Pockets: 20 · best druggability 0.78

Structure

electron microscopy · 1 distinct chain · 71% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Neutral amino acid transporter a	protein	428	71% helix, 4% strand	P43007

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	783	0.78	0.82	90	empty
2	611	0.78	0.84	77	empty
3	794	0.77	0.81	89	empty
4	234	0.77	0.91	50	empty
5	156	0.75	0.93	33	empty

Interfaces

3 interfaces between chains.

B–C · 1119 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 1102 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 1062 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

7P4I · Structure of human ASCT1 transporter · the same entry in another collection · chain A against A, TM-score 1.00
P43007 · AlphaFold monomer V2.0 prediction for neutral amino acid transporter a (P43007) · a predicted model of the same protein · chain A against A, TM-score 0.61

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43007
Elsewhere: RCSB PDB 7P4I · PDBe 7P4I · UniProt P43007

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