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Cryo EM structure of bison NHA2 in detergent and N-terminal extension helix

Analyse Cryo EM structure of bison NHA2 in detergent and N-terminal extension helix in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7P1I
Type: protein
Length: 884 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitochondrial SODIUM/HYDROGEN exchanger 9B2
UniProt: A0A6P3HVI0
Pockets: 20 · best druggability 0.69

Structure

electron microscopy · 1 distinct chain · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	Mitochondrial SODIUM/HYDROGEN exchanger 9B2	protein	442	74% helix, 0% strand	A0A6P3HVI0

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	367	0.69	0.82	46	empty
2	353	0.68	0.81	44	empty
3	277	0.66	0.82	42	empty
4	90	0.65	0.91	22	empty
5	289	0.65	0.81	41	empty

Interfaces

1 interface between chains.

B–A · 1108 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7P1I · Cryo EM structure of bison NHA2 in detergent and N-terminal extension helix · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A6P3HVI0
Elsewhere: RCSB PDB 7P1I · PDBe 7P1I · UniProt A0A6P3HVI0

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