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2.29 a mycobacterium tuberculosis espb.

Analyse 2.29 a mycobacterium tuberculosis espb. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7P13
Type: protein
Length: 1,743 residues
Chains: 7
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Esx-1 secretion-associated protein espb
UniProt: P9WJD9
Pockets: 19 · best druggability 0.71

Structure

electron microscopy · 1 distinct chain · 65% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G	Esx-1 secretion-associated protein espb	protein	249	65% helix, 0% strand	P9WJD9

Pockets

19 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	569	0.71	0.79	63	empty
2	686	0.70	0.78	58	empty
3	642	0.70	0.78	60	empty
4	624	0.70	0.78	60	empty
5	582	0.70	0.79	56	empty

Interfaces

7 interfaces between chains.

A–G · 938 Å² buried · 12 hydrogen bonds · protein-protein
F–G · 937 Å² buried · 12 hydrogen bonds · protein-protein
D–E · 937 Å² buried · 12 hydrogen bonds · protein-protein
E–F · 935 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 934 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

7P13 · 2.29 A Mycobacterium tuberculosis EspB. · the same entry in another collection · chain G against G, TM-score 1.00
P9WJD9 · AlphaFold monomer V2.0 prediction for esx-1 secretion-associated protein espb (P9WJD9) · a predicted model of the same protein · chain D against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WJD9
Elsewhere: RCSB PDB 7P13 · PDBe 7P13 · UniProt P9WJD9

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