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Cryoem structure of human enterovirus 70 empty particle

Analyse Cryoem structure of human enterovirus 70 empty particle in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7OZJ
Type: protein
Length: 589 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: VP1; VP2; VP3
UniProt: P32537
Pockets: 6 · best druggability 0.68

Structure

electron microscopy · 3 distinct chains · 12% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	VP1	protein	207	11% helix, 37% strand	P32537
B	VP2	protein	175	11% helix, 35% strand	P32537
C	VP3	protein	207	14% helix, 30% strand	P32537

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.68	0.88	31	empty
2	67	0.46	0.83	19	empty
3	114	0.40	0.75	22	empty
4	76	0.32	0.74	14	empty
5	61	0.31	0.76	13	empty

Interfaces

3 interfaces between chains.

A–C · 2542 Å² buried · 33 hydrogen bonds · protein-protein
A–B · 1729 Å² buried · 31 hydrogen bonds · protein-protein
B–C · 1617 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

7OZJ · CryoEM structure of human enterovirus 70 empty particle · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32537
Elsewhere: RCSB PDB 7OZJ · PDBe 7OZJ · UniProt P32537

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