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Crystal structure of human filamin C domains 14-15
Analyse Crystal structure of human filamin C domains 14-15 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7OUU
- Type
- protein
- Length
- 406 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 2 of filamin-C
- UniProt
- Q14315
- Pockets
- 3 · best druggability 0.36
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 2 of filamin-C | protein | 202 | 4% helix, 50% strand | Q14315 |
| B | Isoform 2 of filamin-C | protein | 204 | 4% helix, 51% strand | Q14315 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.36 | 0.79 | 18 | empty |
| 2 | 60 | 0.35 | 0.78 | 21 | empty |
| 3 | 54 | 0.31 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 440 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7OUU · Crystal structure of human filamin C domains 14-15 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14315
- Elsewhere: RCSB PDB 7OUU · PDBe 7OUU · UniProt Q14315
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