Research workbench
Structure, function and characterization of a second pyruvate kinase isozyme in pseudomonas aeruginosa.
Analyse Structure, function and characterization of a second pyruvate kinase isozyme in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7OO1
- Type
- protein
- Length
- 951 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pyruvate kinase
- EC
- 2.7.1.40
- UniProt
- Q9I3L4
- Pockets
- 10 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pyruvate kinase (EC 2.7.1.40) | protein | 474 | 38% helix, 23% strand | Q9I3L4 |
| B | Pyruvate kinase (EC 2.7.1.40) | protein | 477 | 38% helix, 23% strand | Q9I3L4 |
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 586 | 0.82 | 0.87 | 56 | empty |
| 2 | 440 | 0.68 | 0.80 | 48 | empty |
| 3 | 426 | 0.65 | 0.78 | 45 | empty |
| 4 | 130 | 0.61 | 0.86 | 23 | empty |
| 5 | 187 | 0.61 | 0.82 | 35 | empty |
Interfaces
1 interface between chains.
- A–B · 1089 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 7OO1 · Structure, function and characterization of a second pyruvate kinase isozyme in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9I3L4
- Elsewhere: RCSB PDB 7OO1 · PDBe 7OO1 · UniProt Q9I3L4
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