Research workbench
Cenp-a nucleosome in complex with cenp-C
Analyse Cenp-a nucleosome in complex with cenp-C in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7ON1
- Type
- protein + DNA
- Length
- 1,023 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BJ4_G0006610.MRNA.1.CDS.1; Histone H4; Histone H2B; BJ4_G0007000.MRNA.1.CDS.1; Histone…
- UniProt
- A0A6A5PSM0, A0A6A5Q1V3, A0A6A5PZQ7, A0A6A5PV75, A0A6A5Q1K4
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 8 distinct chains · 64% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, D | BJ4_G0006610.MRNA.1.CDS.1 | protein | 21 | 14% helix, 0% strand | A0A6A5PSM0 |
| b, f | Histone H4 | protein | 79 | 65% helix, 9% strand | A0A6A5Q1V3 |
| d | Histone H2B | protein | 95 | 74% helix, 2% strand | A0A6A5PZQ7 |
| e, a | BJ4_G0007000.MRNA.1.CDS.1 | protein | 97 | 68% helix, 3% strand | A0A6A5PV75 |
| g, c | Histone H2A | protein | 97 | 55% helix, 5% strand | A0A6A5Q1K4 |
| h | Histone H2B | protein | 94 | 72% helix, 2% strand | A0A6A5PZQ7 |
| I | DNA (152-mer) | dna | 123 | — | — |
| J | DNA (123-mer) | dna | 123 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 439 | 0.76 | 0.85 | 45 | empty |
| 2 | 457 | 0.76 | 0.84 | 43 | empty |
| 3 | 326 | 0.68 | 0.83 | 28 | empty |
| 4 | 280 | 0.65 | 0.82 | 35 | empty |
| 5 | 446 | 0.65 | 0.78 | 35 | empty |
Interfaces
44 interfaces between chains.
- I–J · 5576 Ų buried · 419 hydrogen bonds · nucleic-nucleic
- d–c · 2659 Ų buried · 14 hydrogen bonds · protein-protein
- e–f · 2549 Ų buried · 16 hydrogen bonds · protein-protein
- g–h · 2536 Ų buried · 10 hydrogen bonds · protein-protein
- b–a · 2532 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7ON1 · Cenp-A nucleosome in complex with Cenp-C · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A6A5PSM0
- Every structure of UniProt A0A6A5Q1V3
- Every structure of UniProt A0A6A5PZQ7
- Every structure of UniProt A0A6A5PV75
- Every structure of UniProt A0A6A5Q1K4
- Elsewhere: RCSB PDB 7ON1 · PDBe 7ON1 · UniProt A0A6A5PSM0 · UniProt A0A6A5Q1V3 · UniProt A0A6A5PZQ7 · UniProt A0A6A5PV75 · UniProt A0A6A5Q1K4
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