Research workbench
Crystal structure of coelenteramide-bound renilla reniformis luciferase RLUC8-D162A variant
Analyse Crystal structure of coelenteramide-bound renilla reniformis luciferase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7OMR
- Type
- protein
- Length
- 309 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Coelenterazine H 2-monooxygenase
- EC
- 1.13.12.5
- UniProt
- P27652
- Ligands
- CEI
- Pockets
- 1 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Coelenterazine H 2-monooxygenase (EC 1.13.12.5) | protein | 309 | 45% helix, 18% strand | P27652 |
Ligands and binding sites
- CEI · N-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-2-(4-hydroxyphenyl)acetamide · ligand · chains A
- GOL · Glycerol · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 624 | 0.78 | 0.83 | 41 | CEI |
Compared structures
- 7OMR · Crystal structure of coelenteramide-bound Renilla reniformis luciferase RLuc8-D162A… · the same entry in another collection · chain A against A, TM-score 1.00
- P27652 · AlphaFold monomer V2.0 prediction for coelenterazine H 2-monooxygenase (P27652) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27652
- Elsewhere: RCSB PDB 7OMR · PDBe 7OMR · UniProt P27652
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