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Crystal structure of the human NCOA7-as tldc domain

Analyse Crystal structure of the human NCOA7-as tldc domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7OBP
Type: protein
Length: 984 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NCOA7-as
UniProt: H0Y5F6
Pockets: 4 · best druggability 0.80

Structure

x-ray diffraction · 3 distinct chains · 12% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NCOA7-as	protein	165	12% helix, 31% strand	H0Y5F6
B, C, D, E	NCOA7-as	protein	165	12% helix, 32% strand	H0Y5F6
F	NCOA7-as	protein	159	13% helix, 32% strand	H0Y5F6

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	622	0.80	0.85	54	empty
2	614	0.80	0.85	55	empty
3	482	0.58	0.73	51	empty
4	321	0.52	0.74	31	empty

Interfaces

9 interfaces between chains.

A–D · 559 Å² buried · 10 hydrogen bonds · protein-protein
E–F · 559 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 557 Å² buried · 11 hydrogen bonds · protein-protein
C–F · 555 Å² buried · 12 hydrogen bonds · protein-protein
B–D · 554 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

7OBP · Crystal structure of the human NCOA7-AS TLDc domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H0Y5F6
Elsewhere: RCSB PDB 7OBP · PDBe 7OBP · UniProt H0Y5F6

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