Research workbench
Pseudo-atomic model for HSP26 residues 63 to 214. please be advised that the target MAP is not of sufficient resolution to unambiguously position backbone or side chain atoms. this model represents a likely fit.
Analyse Pseudo-atomic model for HSP26 residues 63 to 214. please be advised that the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7OA6
- Type
- protein
- Length
- 586 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock protein 26
- UniProt
- P15992
- Pockets
- 9 · best druggability 0.72
Structure
electron microscopy · 3 distinct chains · 2% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, I | Heat shock protein 26 | protein | 152 | 5% helix, 32% strand | P15992 |
| J | Heat shock protein 26 | protein | 116 | 0% helix, 29% strand | P15992 |
| X | Heat shock protein 26 | protein | 14 | 0% helix, 14% strand | P15992 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 538 | 0.72 | 0.81 | 62 | empty |
| 2 | 489 | 0.66 | 0.78 | 65 | empty |
| 3 | 108 | 0.65 | 0.89 | 29 | empty |
| 4 | 166 | 0.64 | 0.85 | 22 | empty |
| 5 | 51 | 0.47 | 0.85 | 19 | empty |
Interfaces
7 interfaces between chains.
- I–J · 2316 Ų buried · 48 hydrogen bonds · protein-protein
- A–B · 2204 Ų buried · 33 hydrogen bonds · protein-protein
- B–J · 986 Ų buried · 18 hydrogen bonds · protein-protein
- I–X · 550 Ų buried · 13 hydrogen bonds · protein-protein
- B–I · 536 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 7OA6 · Pseudo-atomic model for Hsp26 residues 63 to 214. Please be advised that the target map… · the same entry in another collection · chain X against X, TM-score 1.00
- P15992 · AlphaFold monomer V2.0 prediction for heat shock protein 26 (P15992) · a predicted model of the same protein · chain J against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15992
- Elsewhere: RCSB PDB 7OA6 · PDBe 7OA6 · UniProt P15992
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