Research workbench
Hantaan virus gn in complex with Fab nnhtn-GN2
Analyse Hantaan virus gn in complex with Fab nnhtn-GN2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7O9S
- Type
- protein
- Length
- 770 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab nnhtn-GN2 heavy chain; Fab nnhtn-GN2 light chain; Envelope polyprotein
- UniProt
- A0A077D153
- Ligands
- NAG
- Pockets
- 8 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 9% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Fab nnhtn-GN2 heavy chain | protein | 216 | 6% helix, 51% strand | — |
| L | Fab nnhtn-GN2 light chain | protein | 214 | 6% helix, 53% strand | — |
| A | Envelope polyprotein | protein | 340 | 14% helix, 45% strand | A0A077D153 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
- GOL · Glycerol · additive · 3 copies · chains H, A, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 480 | 0.61 | 0.75 | 51 | GOL |
| 2 | 136 | 0.56 | 0.83 | 28 | empty |
| 3 | 137 | 0.53 | 0.81 | 25 | empty |
| 4 | 107 | 0.52 | 0.82 | 19 | empty |
| 5 | 109 | 0.49 | 0.81 | 21 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1942 Ų buried · 23 hydrogen bonds · protein-protein
- H–A · 587 Ų buried · 12 hydrogen bonds · protein-protein
- L–A · 425 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 7O9S · Hantaan virus Gn in complex with Fab nnHTN-Gn2 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A077D153
- Elsewhere: RCSB PDB 7O9S · PDBe 7O9S · UniProt A0A077D153
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