Research workbench
Crystal structure of human mitochondrial ferritin (hmtf) FE(II)-loaded for 15 minutes showing either a dioxygen or a superoxide anion coordinated to iron ions in the ferroxidase site
Analyse Crystal structure of human mitochondrial ferritin (hmtf) FE(II)-loaded for 15… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7O67
- Type
- protein
- Length
- 173 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferritin, mitochondrial
- EC
- 1.16.3.1
- UniProt
- Q8N4E7
- Ligands
- FE2, OXY, CL
- Pockets
- 1 · best druggability 0.28
Structure
x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ferritin, mitochondrial (EC 1.16.3.1) | protein | 173 | 72% helix, 0% strand | Q8N4E7 |
Ligands and binding sites
- FE2 · Fe (II) ion · metal · 9 copies · chains A
- OXY · Oxygen molecule · ion · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.28 | 0.74 | 13 | empty |
Compared structures
- 7O67 · Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 15 minutes… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8N4E7 · AlphaFold monomer V2.0 prediction for ferritin, mitochondrial (Q8N4E7) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N4E7
- Elsewhere: RCSB PDB 7O67 · PDBe 7O67 · UniProt Q8N4E7
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