Research workbench
Crystal structure of the anti-pas Fab 3.1 in complex with its epitope peptide
Analyse Crystal structure of the anti-pas Fab 3.1 in complex with its epitope peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7O33
- Type
- protein
- Length
- 447 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-pas Fab 3.1 chimeric light chain; Anti-pas Fab 3.1 chimeric heavy chain; Apsa…
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Anti-pas Fab 3.1 chimeric light chain | protein | 219 | 5% helix, 51% strand | — |
| H | Anti-pas Fab 3.1 chimeric heavy chain | protein | 215 | 8% helix, 53% strand | — |
| P | Apsa epitope peptide | protein | 13 | 0% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 660 | 0.64 | 0.74 | 76 | empty |
| 2 | 198 | 0.50 | 0.76 | 29 | empty |
| 3 | 56 | 0.31 | 0.76 | 14 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1797 Ų buried · 16 hydrogen bonds · protein-protein
- H–P · 595 Ų buried · 7 hydrogen bonds · protein-protein
- L–P · 403 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 1 modified (disulfide, cyclization).
Compared structures
- 7O33 · Crystal structure of the anti-PAS Fab 3.1 in complex with its epitope peptide · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7O33 · PDBe 7O33
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.